Team

Dr. Natalia Misciattelli

Chief Executive Officer

Dr. Misciattelli has more than 25 years of experience as an executive in the life sciences industry. She previously served as Chief Business Officer for immuno-oncology company, NovalGen, and prior to that served as SVP Strategy & Operations for gene therapy company, Freeline. Dr. Misciattelli started her career in finance with Arthur Andersen in London followed by a period in corporate development at General Electric Healthcare and went on to gain broad sector experience in the life sciences internationally as a partner at PA Consulting. She holds a B.Sc. and a Ph.D. in Marine Microbiology from Bangor University, University of Wales, UK.

Dr. Naveed Shams

Chief Development and Medical Officer

Naveed is a Bio-Pharmaceutical and Medical Device Executive with 26 Years’ experience in Global Bio-Pharmaceutical Business across large multinationals and startups.

Prior to joining Avvantgarde Bio, he was the Chief Science Officer and managing Translational Research and Early Development efforts at ProQR Therapeutics, A Dutch, Clinical Stage, Oligonucleotide (RNA) platform Company. The focus of translation was on rare ophthalmic diseases including, retinitis pigmentosa-associated with syndromic or non-syndromic Ushers disease, autosomal dominant retinitis pigmentosa, Fuchs corneal dystrophy. His experience includes transforming and managing the US business of a Japanese Ophthalmic company Santen Pharmaceuticals, leading its 450 personal Global R&D Organization with an annual budget of US$ 250 million. Separately he was also accountable for the Company’s venture investments in line with mid to long-term plans.

Recognized as a significant contributor in the Ophthalmic Drug Development and Sciences space globally. Established the Ophthalmology Development Group at Genentech and led the development of Lucentis as a breakthrough in treating wet-Age-related macular degeneration, over $6 billion in annualized peak sales worldwide.

Naveed’s experience Drug and Device spans across ophthalmic diseases and product classes including oligonucleotide / RNA therapy, cell therapy for ceographic atrophy, cyclic peptides for intraocular inflammation, biologics for non-responders to VEGF therapy, prostaglandin receptor agonists to modulate aqueous humor dynamics, muscarinic antagonists for myopia, devices for subjects with end-stage glaucoma.

Extensive experience in global market access programs, health economics, macro and micro level healthcare issues impacting biotech and Pharma sectors. Experience in the working at the interface of technology and medicine to address quality of life issues.  Including leveraging machine learning and neural networks to enhance drug discovery and improve probability technical success.

Prof. Alberto Auricchio

Founder

Alberto Auricchio, PhD is Coordinator of the Molecular Therapy Program at TIGEM and Professor of Medical Genetics at University “Federico II” in Naples, Italy
He is co-author of over 140 peer-reviewed publications and inventor of several patents related to the use of viral vectors for gene therapy.
Dr Auricchio is Executive Board Member of the European Society of Gene and Cell Therapy and acts as Scientific Advisory Board member of several gene therapy companies (Odylia, Gyroscope, Alia Therapeutics, Innovavector).

Prior to AAVantgarde he contributed to the development of Luxturna, the first approved gene therapy for an ocular disease and has developed AAV-based gene therapy for a rare lysosomal storage disease from discovery up to first-in-human (the first in vivo gene therapy clinical trial in Italy).

Dr. Rita Ferla

Project Manager

Rita holds a Master degree in Cellular and Molecular Biology and a PhD in Cellular and Molecular Oncopathology from the University of Palermo. She performed her post-doctorate at Telethon Institute of Genetics and Medicine (TIGEM) in the group of Dr. Alberto Auricchio.

She has more than 10-year experience in AAV gene therapy with a particular focus in translational research, CMC and IND/CTA enabling studies.

Prior to AAVantgarde, she played a major part in the development of AAV-based gene therapy for a lysosomal storage disease, from discovery up to first-in-human and in AAV-based platforms for large gene delivery to the retina.